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The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage

Kemin Qin1, Yicong Chen2, Haiyin Long1

  • 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi.

Medicine
|May 18, 2019
PubMed

Insights

Lung cancer patients experiencing cerebral hemorrhage show distinct biomarkers. Lengthened prothrombin time, elevated CEA, and CA199 levels are key indicators for lung cancer-related cerebral hemorrhage (LCRCH).

Area of Science:

  • Oncology
  • Neurology
  • Biochemistry

Background:

  • Cerebral hemorrhage is a known complication in lung cancer (LC) patients.
  • The pathogenesis and specific biomarkers for lung cancer-related cerebral hemorrhage (LCRCH) are not well understood.

Purpose of the Study:

  • To investigate the pathogenesis and identify plasma biomarkers for LCRCH.

Main Methods:

  • Retrospective review of 56 acute cerebral hemorrhage patients with active LC and no conventional vascular risks (LCRCH group).
  • Comparison with 112 age, gender, and cancer subtype-matched active LC patients without hemorrhage (control group).
  • Analysis included prothrombin time (PT), plasma carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 199 (CA199), and platelet (PLT) levels.

Main Results:

  • LCRCH patients often presented with lobar hemorrhages, typically in advanced-stage adenocarcinoma with poor short-term prognosis.
  • LCRCH patients exhibited significantly lengthened PT, elevated plasma CEA, CA125, and CA199, and decreased PLT levels compared to controls.
  • Multivariate analysis identified lengthened PT, elevated plasma CEA, and CA199 as independent risk factors for LCRCH.

Conclusions:

  • Lengthened PT, elevated plasma CEA, and CA199 levels are associated with the pathogenesis of LCRCH.
  • An index derived from these independent risk factors could serve as a specific biomarker for LCRCH.

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