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Functional Glyco-Nanogels for Multivalent Interaction with Lectins.

Jo Sing Julia Tang¹, Sophia Rosencrantz², Lucas Tepper³

¹Fraunhofer Institute for Applied Polymer Research IAP, Biofunctionalized Materials and (Glyco)Biotechnology, Geiselbergstr. 69, 14476 Potsdam, Germany. josing.tang@iap.fraunhofer.de.

Molecules (Basel, Switzerland)

|May 18, 2019

Summary

This summary is machine-generated.

Researchers developed novel glyco-nanogels to block pathogen interactions. These functional glycogels show promise as alternatives or adjuncts to antibiotics for treating infections caused by bacteria like Pseudomonas aeruginosa.

Keywords:

glycans glycogels glycopolymers lectins multivalency nanogels precipitation polymerization

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Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Published on: September 15, 2011

Area of Science:

Biochemistry and Glycoscience
Materials Science
Infectious Diseases

Background:

Glycan-protein interactions are crucial for cellular processes and host-pathogen adhesion.
Pseudomonas aeruginosa infections are a significant cause of nosocomial infections, often mediated by glycan interactions.
Developing glycan derivatives as pathoblockers is a promising strategy to combat bacterial infections.

Purpose of the Study:

To synthesize novel glycomonomers and polymerize them into crosslinked glyco-nanogels.
To investigate the potential of these glyco-nanogels as pathoblockers against Pseudomonas aeruginosa.
To evaluate the influence of glyco-nanogels on pathogen virulence factor secretion.

Main Methods:

Microwave-assisted, protecting-group-free synthesis of glycomonomers (lactose, melibiose, fucose).
Precipitation polymerization of glycomonomers with NIPAM to form crosslinked glyco-nanogels.
Characterization of glyco-nanogels using lectin binding studies and investigation of reaction parameter influence.

Main Results:

Synthesized and polymerized glycomonomers into functional glyco-nanogels.
Demonstrated size and composition-dependent inhibition of lectin binding by the glyco-nanogels.
Observed significantly stronger inhibition with multivalent glycan presentation compared to unmodified saccharides.
Initial studies with Pseudomonas aeruginosa showed a notable influence on virulence factor secretion.

Conclusions:

Functional glycogels can effectively inhibit glycan-mediated interactions.
The multivalent presentation of glycans on nanogels enhances inhibitory effects.
Glycogels show potential as novel therapeutic agents, possibly as alternatives or adjuncts to antibiotics for treating Pseudomonas aeruginosa infections.