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Sofosbuvir induced leucocytoclasic vasculitis: a case report.

Elena Campione1, Annunziata Dattola2, Monia Di Prete3

  • 1Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy. campioneelena@hotmail.com.

BMC Dermatology
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Summary
This summary is machine-generated.

Sofosbuvir therapy for hepatitis C virus (HCV) can trigger leucocytoclastic vasculitis. This drug-induced vasculitis resolved after discontinuing Sofosbuvir treatment, highlighting a potential adverse effect.

Keywords:
Hepatitis CLeukocytoclasic vasculitisSofosbuvir

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Area of Science:

  • Hepatology
  • Dermatology
  • Pharmacology

Background:

  • Hepatitis C virus (HCV) infection is a significant global health concern.
  • Sofosbuvir is a key antiviral medication used in HCV treatment.
  • Drug-induced vasculitis is a recognized, albeit uncommon, adverse reaction to medications.

Observation:

  • A 53-year-old male patient developed palpable purpura.
  • The rash appeared approximately one month after initiating Sofosbuvir for HCV genotype 1 infection.
  • The patient presented to the dermatology department with these symptoms.

Findings:

  • A temporal association was observed between Sofosbuvir initiation and the onset of leucocytoclastic vasculitis.
  • The vasculitis persisted despite various treatments but resolved completely upon cessation of Sofosbuvir.
  • This clinical course strongly suggests a drug eruption induced by Sofosbuvir.

Implications:

  • This case underscores the importance of considering drug-induced vasculitis in patients on Sofosbuvir therapy.
  • A multidisciplinary approach is crucial for managing patients with liver disease and associated dermatological conditions.
  • Awareness of this potential adverse effect can guide clinical decision-making and patient monitoring.