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Cervical Glandular Neoplasia: Classification and Staging.
Gulisa Turashvili1, Kay J Park2
1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Surgical Pathology Clinics
|May 18, 2019
Summary
Endocervical adenocarcinomas (EAs) are often HPV-driven. A new classification system integrates morphology and pathogenesis to better distinguish HPV and non-HPV subtypes of EA for improved diagnosis and treatment.
Area of Science:
- Gynecologic Pathology
- Oncology
- Virology
Background:
- Endocervical adenocarcinomas (EAs) comprise 25% of cervical cancers.
- Most EAs (85%) are associated with high-risk human papillomavirus (HPV) infection, typically the usual type.
- Non-HPV-driven subtypes have unique features and prognoses, necessitating improved classification.
Purpose of the Study:
- To review a new classification system for endocervical adenocarcinomas.
- To highlight the integration of morphology, cause/pathogenesis, and biological behavior.
- To improve the distinction between HPV-driven and non-HPV-driven EA subtypes.
Main Methods:
- Review of existing literature and proposed classification criteria.
- Analysis of morphological features associated with HPV status.
- Integration of etiological and pathogenetic data for classification.
Main Results:
- The International Endocervical Adenocarcinoma Criteria and Classification system offers a comprehensive approach.
- This system distinguishes between HPV-driven and non-HPV-driven EAs based on integrated criteria.
- It aims to provide clinically relevant and reproducible diagnostic criteria.
Conclusions:
- Accurate classification of EAs is crucial due to differing prognoses.
- The proposed classification system facilitates better understanding and management of EA subtypes.
- Improved classification aids in tailoring treatment strategies for cervical cancer patients.
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