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Updated: Jan 24, 2026

Generation and Culturing of High-Grade Serous Ovarian Cancer Patient-Derived Organoids
Published on: January 6, 2023
Ovarian High-Grade Serous Carcinoma: Assessing Pathology for Site of Origin, Staging and Post-neoadjuvant
1Department of Pathology, Queen's Hospital, Rom Valley Way, Romford RM7 0AG, UK.
Abstract:
High-grade serous (HGSC) stands apart from the other ovarian cancer histotypes in being the most frequent, in occurring as part of a genetic predisposition in a significant proportion of cases, and in having the poorest clinical outcomes. Although the pathologic diagnosis of HGSC is now made with high accuracy, there remain areas of disagreement regarding viewpoints on tissue site of origin and designation of primary site, with impact on staging in low-stage cases, as well as difficulties in reproducible and clinically relevant reporting of HGSC in specimens taken after neoadjuvant chemotherapy. These areas are discussed in the current article.
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