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Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Mitral Valve Prolapse II: Assessment and Management01:22

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Valve Prolapse III: Nursing Management01:19

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The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Fibril-associated Collagen01:11

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Related Experiment Video

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Robotic Ablation of Atrial Fibrillation
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Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation.

Joseph J DeRose1, Donna M Mancini2, Helena L Chang2

  • 1Department of Cardiothoracic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.

Journal of the American College of Cardiology
|May 18, 2019
PubMed
Summary

Permanent pacemaker implantation is more common after mitral valve surgery with atrial fibrillation ablation. This procedure increases the risk of one-year mortality, highlighting the need for careful patient selection.

Keywords:
biatrial mazecardiac surgerypermanent pacemakerpulmonary vein isolationvalvular heart disease

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Electrophysiology

Background:

  • Mitral valve surgery (MVS) with concomitant ablation for atrial fibrillation (AF) leads to a higher incidence of permanent pacemaker (PPM) implantation compared to MVS alone.
  • Understanding the risk factors and outcomes associated with PPM implantation in this patient population is crucial for clinical decision-making.

Purpose of the Study:

  • To identify independent risk factors for PPM implantation in patients undergoing MVS with or without AF ablation.
  • To evaluate the impact of PPM implantation on postoperative outcomes, including length of stay, readmissions, and 1-year mortality.

Main Methods:

  • A randomized trial involving 243 patients with AF undergoing MVS without prior PPM placement.
  • Patients were assigned to either MVS alone or MVS with ablation (pulmonary vein isolation or biatrial maze).
  • Competing risk models were used to analyze the association between PPM implantation and various risk factors, as well as its effect on clinical outcomes.

Main Results:

  • The overall PPM implantation rate within one year was 14.4%, with 83% occurring during the initial hospitalization.
  • Independent risk factors for PPM implantation included AF ablation, multivalve surgery, and NYHA functional class III/IV.
  • PPM implantation was associated with a significantly increased risk of 1-year mortality (HR: 3.21; p=0.05).

Conclusions:

  • Atrial fibrillation ablation, multivalve surgery, and advanced NYHA functional class are significant risk factors for permanent pacemaker implantation after MVS.
  • Permanent pacemaker implantation following MVS is associated with a substantial increase in 1-year mortality.