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Related Experiment Video

Updated: Jan 24, 2026

Acquisition of High-Quality Digital Video of Drosophila Larval and Adult Behaviors from a Lateral Perspective
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Achieving appropriate medication for older adults: A multidimensional perspective.

Luis Mieiro1, Jean-Baptiste Beuscart2, Wilma Knol3

  • 1Older People's Services - Whipps Cross University Hospital - Barts Health NHS Trust; MRC Unit for Lifelong Health and Ageing - University College of London, United Kingdom.

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Summary

Achieving appropriate medication for older adults is complex. Patient-centric drug development and clinician involvement are crucial to avoid inappropriate polypharmacy, improving patient outcomes.

Keywords:
Medication reviewOlder adultsPatient-centric medication

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Area of Science:

  • Geriatric Medicine
  • Clinical Pharmacy
  • Pharmacology

Background:

  • Polypharmacy, the use of multiple medications, is a growing concern, particularly in older adults.
  • Current research often overlooks the root causes of inappropriate polypharmacy, focusing mainly on drug appropriateness.
  • Exclusion of older, frail patients from clinical trials limits understanding of drug efficacy in this demographic.

Purpose of the Study:

  • To conduct a narrative review on the causes of inappropriate polypharmacy in older adults.
  • To explore strategies for avoiding inappropriate polypharmacy through patient-centric drug development and regulatory adaptation.
  • To emphasize the need for multidisciplinary collaboration in achieving appropriate medication use.

Main Methods:

  • Narrative review synthesizing insights from clinical, pharmaceutical, and regulatory perspectives.
  • Analysis of factors contributing to inappropriate polypharmacy, including trial design and drug formulation.
  • Discussion of the role of healthcare technology, patient advocacy, and communication.

Main Results:

  • Inappropriate polypharmacy arises from multiple factors, including trial exclusion of older adults and suboptimal drug design.
  • Patient-centric drug product development, considering older adults' characteristics, is essential for effective medication.
  • Existing criteria (e.g., STOPP/START) offer guidance but do not fully address the complexity of medication appropriateness.

Conclusions:

  • Achieving appropriate medication for older adults requires a holistic approach beyond simple drug review.
  • Integrating diverse disciplines, patient needs, and expectations is vital for successful polypharmacy management.
  • Enhanced drug development processes and regulatory frameworks are necessary to support appropriate medication use.