Involvement of microRNAs in physiological and pathological processes in asthma

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Seyed Reza Mousavi1, Ali Ahmadi2, Sadegh Azimzadeh Jamalkandi1

  • 1Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Journal of Cellular Physiology
|May 18, 2019
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in asthma pathogenesis, influencing gene expression and immune responses. This review explores their role in asthma and potential as diagnostic and therapeutic biomarkers.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Asthma is a common respiratory disease characterized by airway inflammation and obstruction.
  • Pathogenesis involves genetic and environmental factors, with Th2 immune responses playing a significant role.
  • Mast cells and eosinophils are key cellular players in asthma-related inflammation.

Purpose of the Study:

  • To review the current understanding of microRNA (miRNA) involvement in asthma pathogenesis.
  • To explore the potential of miRNAs as diagnostic biomarkers for asthma.
  • To investigate the therapeutic potential of miRNAs in managing asthma.

Main Methods:

  • Literature review of studies investigating miRNAs in asthma.
  • Analysis of miRNA regulatory mechanisms in airway inflammation.
  • Examination of miRNA expression patterns in asthma patients.

Main Results:

  • miRNAs significantly regulate gene expression involved in asthma.
  • Specific miRNAs are implicated in Th2-mediated immune responses and inflammation.
  • Dysregulated miRNA expression is observed in asthma.

Conclusions:

  • miRNAs are crucial in the molecular mechanisms underlying asthma.
  • miRNAs show promise as potential diagnostic and therapeutic targets for asthma.
  • Further research is warranted to fully elucidate miRNA roles and applications in asthma.
Keywords:
asthmadiagnostic and therapeutic biomarkersmicroRNAs

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