Related Experiment Video
Updated: Jan 24, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
LncRNA PAPAS promotes oral squamous cell carcinoma by upregulating transforming growth factor-β1
Panpan Zhang1,2,3, Ying Liu1, Chong Li4
1The Center of Esthetic Dentistry, Jinan Stomatological Hospital, Jinan, Shandong, P.R. China.
Abstract:
PAPAS is a recently identified long noncoding RNA (lncRNA) with inhibitory effects on ribosomal RNA synthesis. We studied the role of PAPAS in oral squamous cell carcinoma (OSCC). In the present study we showed that plasma PAPAS and transforming growth factor β1 (TGF-β1) were both upregulated in patients with OSCC, and were positively correlated only in patients with OSCC. Plasma levels of PAPAS were not significantly affected by AJCC stages and upregulation of PAPAS distinguished stage I OSCC patients from healthy controls. High plasma levels of PAPAS were followed by low overall survival rate. PAPAS overexpression led to upregulation of TGF-β1 in OSCC cells, while TGF-β1 treatment failed to significantly affect PAPAS. PAPAS overexpression and exogenous TGF-β1 treatment led to promoted invasion and migration of OSCC cells. In addition, TGF-β inhibitor attenuated the effects of PAPAS overexpression. Therefore, lncRNA PAPAS may promote OSCC by upregulating TGF-β1.
Related Concept Videos
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Bacterial Transformation
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Factors Influencing Microbial Growth: pH
The Eukaryotic Promoter Region

