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Antibacterial-containing dental adhesives' effects on oral pathogens and on Streptococcus mutans biofilm: Current
Carolina Bosso André1, Daniel Cn Chan2, Marcelo Giannini3
1Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.
Purpose:
To describe the literature findings regarding commercially available antibacterial-containing dental adhesives and the futures perspectives of this field.
Results:
High-risk caries patients could yield benefits from restorative materials containing antibacterial properties in order to reduce the recurrent caries formation. Dental adhesives with antibacterial agents may reduce restoration replacement, as recurrent caries is still one of the major reasons for replacing a resin restoration. Literature results of three commercially available adhesives: Gluma 2Bond, Clearfil SE Protect and Peak Universal Bond, containing glutaraldehyde, MDPB and chlorhexidine, respectively indicates that Clearfil SE Protect seems to have better results against oral pathogens and on Streptococcus mutans biofilm. Besides the promising findings, clinical studies are still necessary in order to validate the clinical efficacy when exposed to a more complex environment and the long-term effect of either commercially available materials, experimental antibacterial monomers or antibacterial incorporations. As a suggestion of this article and according to the current scientific trends in this specific field, future directions should focus on restorative materials with therapeutic components targeting the virulence factors of cariogenic biofilm with minimal toxicity and side effects, and long-term action.
Clinical Significance:
Antibacterial-containing dental adhesives may have therapeutic effects, working as an additional source to reduce recurrent caries development in patients with high-risk of caries, and consequently the reduction in restoration replacements.