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Updated: Jan 24, 2026

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
Release of calcium ions from particulate monosodium titanates for dental mineralization applications
Jeanie L Drury1, Yen-Wei Chen2, Bryce J Plancich1
1Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, Washington, USA.
Purpose:
The calcium ion [Ca(II)] release from monosodium titanates (MST) complexed to calcium ions [Ca(II)], referred to as MST-Ca(II), was examined under varying incubation times, pH conditions, and ion equilibrium disruptions.
Methods:
Sample supernatants were analyzed for Ca(II) using the QuantiChrom Calcium Assay Kit.
Results:
No Ca(II) was detected in native MST (control) supernatants but was detected in MST-Ca(II) supernatants. At pH 7, Ca(II) release increased from 0 to 2.5 mg/dL over 3 days (P< 0.05 compared to MST control), remaining constant over the completed incubation times. At pH 5, 15 mg/dL of Ca(II) was immediately released with no further release. When the pH was modulated pH 4 to pH 9, Ca(II) concentration dropped from 25 mg/dL to ~0 mg/dL. Finally, when equilibrium was disrupted by partial replacement of the supernatant with sterile water, Ca(II) release was ongoing, reaching a cumulative total of 20 mg/dL over 35 days.
Clinical Significance:
The current results suggest that particulate MST-Ca(II) complexes exhibit sustained release of calcium, and that release might be customized by conditions of pH and ionic strength. Thus, these complexes appear promising for biological applications where calcium-mediated mineralization or re-mineralization are desired.
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