Related Experiment Video

Updated: Jan 24, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

763

Ventricular-ventricular interaction variables correlate with surrogate variables of clinical outcome in children with

Martin Koestenberger1,2, Hannes Sallmon2,3, Alexander Avian4

  • 11 Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Austria.

Pulmonary Circulation
|May 18, 2019
PubMed

Insights

Ventricular-ventricular interactions (VVI) in pediatric pulmonary hypertension (PH) are key indicators of disease severity. Echocardiography reveals that left ventricular eccentricity index and RV/LV ratio correlate with poorer outcomes and higher NT-proBNP levels.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Echocardiography

Background:

  • Biventricular dimensions, function, and ventricular-ventricular interactions (VVI) are crucial in adult pulmonary hypertension (PH) assessment.
  • Data on VVI in pediatric PH is limited, necessitating further investigation into its role in disease severity and progression.

Purpose of the Study:

  • To investigate the correlation between echocardiographic VVI variables and clinical/hemodynamic parameters in children with PH.
  • To determine if VVI indicators can predict disease severity and progression in pediatric PH.

Main Methods:

  • Echocardiography was used to assess left and right heart dimensions and function, including end-systolic LV eccentricity index (LVEI) and RV/LV dimension ratio in 57 children with PH.
  • Variables were correlated with New York Heart Association (NYHA) functional class (FC), NT-proBNP levels, and invasive hemodynamic measurements like pulmonary vascular resistance index (PVRi).

Main Results:

  • Higher NYHA FC correlated with lower LV ejection fraction (LVEF) and increased LVEI, indicating left ventricular compression.
  • Severe PH (higher sPAP/sSAP ratio, PVRi) was associated with increased RV/LV and right-to-left atrial dimension ratios.
  • Worsening PH severity correlated with reduced RV function (tricuspid annular plane systolic excursion) and increased RV/right atrial dimensions.
  • NT-proBNP levels showed significant correlation with PH severity (sPAP/sSAP ratio) and NYHA FC.

Conclusions:

  • Echocardiographic VVI variables, specifically LVEI and RV/LV dimension ratio, are significant indicators of disease severity in pediatric PH.
  • These VVI parameters correlate with poorer functional class, worse hemodynamics, and elevated NT-proBNP levels.
  • Ventricular interdependence plays a critical role in the pathophysiology and clinical presentation of pediatric PH, highlighting the utility of echocardiography for comprehensive assessment.

Keywords:
New York Health Association functional classleft ventricular eccentricity indexpediatric pulmonary hypertensionventricular–ventricular interactions

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