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Updated: Jan 24, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Comprehensive left ventricular myocardial deformation assessment in children with Kawasaki disease

Aura A Sanchez1,2, Sara K Sexson Tejtel1, Myriam E Almeida-Jones1,3

  • 1Section of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

Congenital Heart Disease
|May 18, 2019
PubMed

Insights

Children with Kawasaki disease (KD) show subtle decreases in myocardial strain rate, particularly those with coronary artery aneurysms (CAAs). This finding suggests potential long-term cardiac issues in KD patients with CAAs.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Rheumatology

Background:

  • Kawasaki disease (KD) can lead to coronary artery aneurysms (CAAs) and chronic vasculopathy.
  • Early detection of myocardial ischemia in KD patients with CAAs is challenging.
  • Myocardial deformation analysis offers a method for early detection of cardiac performance alterations.

Purpose of the Study:

  • To investigate differences in myocardial deformation between KD patients with and without CAAs.
  • To assess if myocardial deformation analysis can identify early signs of cardiac dysfunction in KD.

Main Methods:

  • Cross-sectional study of 123 echocardiograms from 103 children with KD.
  • Two-dimensional speckle tracking (2DSTE) used for myocardial deformation analysis.
  • Analysis included left ventricular global longitudinal strain rate (GLSSR) and global circumferential systolic strain rate (GCSSR), peak torsion, and torsion rate across different KD phases.

Main Results:

  • Myocardial deformation was within normal limits in all KD phases.
  • GLSSR, GCSSR, peak torsion, and torsion rate were lower in the convalescent/chronic phase compared to the acute phase (P < .05).
  • The convalescent/chronic phase subgroup with CAAs exhibited significantly lower GLSSR and GCSSR compared to those without CAAs (P < .05).

Conclusions:

  • Children in the convalescent/chronic phase of KD demonstrate a subtle, albeit normal range, decrease in strain rate compared to the acute phase.
  • This decrease in strain rate is more pronounced in KD patients with CAAs.
  • Longitudinal studies are recommended to determine if low-normal strain rate predicts future decreased myocardial function.
Abstract

Keywords:
Kawasaki diseasecoronary artery aneurysmsmyocardial deformation

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