Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

878
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
878
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.2K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.6K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.6K
The Carbon Cycle01:14

The Carbon Cycle

43.3K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
43.3K
Carbon Skeletons01:12

Carbon Skeletons

114.6K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
114.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hybrid strategy of left atrial appendage closure on top of anticoagulation in patients with prior anticoagulation failure: a multicenter study.

Polish archives of internal medicine·2026
Same author

Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases.

Biomolecules·2026
Same author

Development and implementation of ICF-based functioning assessment in polish medical rehabilitation: a comprehensive system‑level pilot study.

BMC health services research·2026
Same author

Evaluation of Intra-Amniotic Infection Detection Based on Available Diagnostic Methods.

Medicina (Kaunas, Lithuania)·2025
Same author

Workplace Health Interventions Targeting Cardiovascular Diseases and Diabetes Mellitus for Blue-Collar Workers: Protocol for a Scoping Review.

JMIR research protocols·2025
Same author

Supramolecular assembly of novel achatin structurally similar peptide as potential G protein-coupled receptors anticancer ligands: focus on its pseudo-macrocycle nature.

Royal Society open science·2025

Related Experiment Video

Updated: Jan 24, 2026

Detection of Abnormal Prion Protein by Immunohistochemistry
06:38

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

3.7K

Repolarization abnormalities in carbon monoxide poisoning - a case report.

Michał Kałowski1, Maksymilian Janicki1, Rafał Berner1

  • 1Department of Electrocardiology, Medical University of Lodz, Poland.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|May 18, 2019
PubMed
Summary

Severe carbon monoxide (CO) poisoning can cause significant heart repolarization abnormalities, including QT interval prolongation. Prompt medical attention is crucial for managing these cardiac effects in CO intoxication cases.

Keywords:
QT interval prolongationcarbon monoxide poisoningelectrocardiogramischemiarepolarization

More Related Videos

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
05:18

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

702
Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis
07:57

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis

Published on: August 15, 2018

14.7K

Related Experiment Videos

Last Updated: Jan 24, 2026

Detection of Abnormal Prion Protein by Immunohistochemistry
06:38

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

3.7K
Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters
05:18

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

702
Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis
07:57

Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis

Published on: August 15, 2018

14.7K

Area of Science:

  • Cardiology
  • Toxicology
  • Emergency Medicine

Background:

  • Carbon monoxide (CO) poisoning is a global health concern, frequently leading to fatal outcomes.
  • CO intoxication impairs oxygen delivery, causing hypoxia and lactic acidosis, with the myocardium being highly susceptible to damage.
  • Cardiac complications, including repolarization abnormalities, are recognized but require further elucidation.

Observation:

  • A case report details a 66-year-old male with severe CO poisoning presenting with significant electrocardiogram (ECG) abnormalities.
  • Initial ECG revealed diffuse ST segment depression and marked QT interval prolongation (QTcB 595ms).
  • Other potential causes for QT prolongation were systematically excluded, and echocardiography showed no cardiac dysfunction.

Findings:

  • The patient exhibited severe repolarization abnormalities on ECG following CO exposure.
  • QT interval prolongation was a prominent feature, persisting even after initial management.
  • ECG findings showed partial normalization of ST segments and slight QT shortening within 6 hours.

Implications:

  • This case highlights the potential for severe cardiac repolarization disturbances in CO poisoning.
  • It underscores the importance of comprehensive cardiac evaluation in patients with significant CO exposure.
  • Understanding these cardiac manifestations is vital for effective clinical management and prognosis in CO intoxication.