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Precision medicine in primary biliary cholangitis

Vincenzo Ronca1, Alessio Gerussi1, Laura Cristoferi1

  • 1Division of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Journal of Digestive Diseases
|May 18, 2019
PubMed

Insights

Precision medicine offers personalized treatment for primary biliary cholangitis (PBC), moving beyond one-size-fits-all care. This approach utilizes patient-specific characteristics for optimal therapeutic strategies.

Area of Science:

  • Hepatology and Gastroenterology
  • Translational Medicine
  • Pharmacogenomics

Background:

  • Primary biliary cholangitis (PBC) management historically relied on a uniform approach.
  • Recent advancements include second-line therapies like obeticholic acid and risk stratification scores.
  • A paradigm shift towards personalized medicine is emerging for PBC treatment.

Purpose of the Study:

  • To review current risk stratification tools for primary biliary cholangitis.
  • To explore the application of precision medicine in managing PBC.
  • To outline a pathway for integrating precision medicine into clinical practice.

Main Methods:

  • Literature review of clinical practice guidelines and research on PBC management.
  • Analysis of existing risk stratification scores and their biochemical basis.
  • Discussion of the principles and potential of precision medicine in PBC.

Main Results:

  • Obeticholic acid represents a significant advancement in second-line PBC treatment.
  • Biochemical risk scores aid in stratifying patients with progressive disease.
  • Emerging drug candidates in late-stage trials further support personalized treatment strategies.

Conclusions:

  • Precision medicine promises tailored treatments for PBC based on individual patient profiles.
  • Integrating precision medicine requires leveraging risk stratification and novel therapeutic options.
  • The future of PBC management involves a patient-centered approach for improved outcomes.
Keywords:
omicsprecision medicineprimary biliary cholangitisrisk stratification

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