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Updated: Aug 8, 2026

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
Published on: August 30, 2012
An odd and serious "disc bulging"!
C Champeaux1, G Abi-Lahoud2, F Larousserie3
1Department of neurosurgery, Lariboisière hospital, 75010 Paris, France; Department of neurosurgery, Sainte-Anne hospital, 75014 Paris, France; Department of neurosurgery, NHNN, university college London hospitals, NHS foundation trust, WC1N 3BG London, UK.
Background And Importance:
Cauda equina syndrome is a common acute medical condition, usually caused by large degenerative disc herniation or metastatic lumbar disease. We describe a patient who presented with a lesion featuring both discal and tumoral characteristics.
Clinical Presentation:
A 41-year-old woman presented with ongoing back pain, progressive lower-limb weakness and sphincter disorder. Magnetic resonance imaging showed a very odd-looking large anterior epidural lesion originating from the L3-L4 space and severely compressing the roots of the cauda equina. Partial surgical decompression was performed in emergency. At a later time, redo surgery was performed to maximize resection, and was unfortunately followed by several complications. After 6 surgical procedures including a ventriculo-peritoneal shunt insertion and intensive rehabilitation, the patient could walk independently with the aid of one crutch. Following collegial review, the diagnosis of low-grade chondrosarcoma of the intervertebral disc was suggested.
Conclusion:
We report on a very unusual and therapeutically challenging spinal tumor diagnosed as low-grade chondrosarcoma of discal origin, an entity never previously described.
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