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Updated: Jan 24, 2026
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?
Joanna Kopecka1, Elena Gazzano1, Barbara Castella2
1Department of Oncology, University of Torino, via Santena 5/bis, 10126, Torino, Italy.
Abstract:
Mitochondria have been considered for a long time only as the principal source of building blocks and energy upon aerobic conditions. Recently they emerged as key players in cell proliferation, invasion and resistance to therapy. The most aggressive tumors are able to evade the immune-surveillance. Alterations in the mitochondria metabolism either in cancer cells or in host immune system cells are involved in such tumor-induced immune-suppression. This review will focus on the main mitochondrial dysfunctions in tumor and immune cell populations determining immune-resistance, and on the therapies that may target mitochondrial metabolism and restore a powerful anti-tumor immune-activity.
Insights
Mitochondria are crucial for cancer growth and immune evasion. Targeting mitochondrial metabolism in cancer and immune cells can overcome tumor-induced immune suppression and restore anti-tumor immunity.
Area of Science:
- Cellular Biology
- Immunology
- Oncology
Background:
- Mitochondria traditionally viewed as energy producers.
- Emerging roles in cancer cell proliferation, invasion, and therapy resistance.
- Aggressive tumors evade immune surveillance, often linked to metabolic alterations.
Purpose of the Study:
- Review mitochondrial dysfunctions in cancer and immune cells.
- Analyze their role in immune resistance.
- Discuss therapies targeting mitochondrial metabolism for anti-tumor immunity.
Main Methods:
- Literature review of mitochondrial roles in cancer immunology.
- Analysis of metabolic pathways in tumor and immune cells.
- Exploration of therapeutic strategies targeting mitochondria.
Main Results:
- Mitochondrial metabolism alterations contribute to tumor immune suppression.
- Dysfunctional mitochondria in cancer cells promote immune evasion.
- Altered mitochondrial function in immune cells impairs anti-tumor responses.
Conclusions:
- Mitochondrial dysfunctions are key drivers of cancer immune resistance.
- Targeting mitochondrial metabolism offers a promising therapeutic avenue.
- Restoring mitochondrial function can enhance anti-tumor immune activity.
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