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Intermittent hypoxemia and oxidative stress in preterm infants
Juliann M Di Fiore1, Maximo Vento2
1Dept of Pediatrics, Case Western Reserve University, Division of Neonatology, Rainbow Babies & Children's Hospital, 11100 Euclid Ave, Cleveland, OH, 44106, United States.
Respiratory Physiology & Neurobiology
|May 18, 2019
Summary
Intermittent hypoxemia (IH) in preterm infants is linked to poor outcomes. This review explores IH patterns, their connection to infant morbidity, and the role of oxidative stress.
Area of Science:
- Neonatal Medicine
- Pediatric Respiratory Medicine
- Developmental Neuroscience
Background:
- Intermittent hypoxemia (IH) is prevalent in extremely preterm infants.
- IH is associated with adverse outcomes like retinopathy of prematurity, bronchopulmonary dysplasia, and neurodevelopmental delays.
- Emerging evidence from animal models suggests specific IH patterns may elevate morbidity risk.
Purpose of the Study:
- To review early postnatal IH patterns in preterm infants.
- To examine the relationship between IH and infant morbidity.
- To explore the role of oxidative stress and reactive oxygen species in IH-related pathology.
Main Methods:
- Literature review of studies on intermittent hypoxemia in preterm infants.
- Analysis of data linking IH patterns to specific morbidities.
- Examination of research on oxidative stress biomarkers in newborns.
- Review of studies investigating the connection between IH and reactive oxygen species.
Main Results:
- Early postnatal IH patterns are common in extremely preterm infants.
- Specific IH patterns are increasingly recognized as risk factors for infant morbidity.
- Oxidative stress is implicated as a potential mechanism in IH-induced pathological cascades.
- Reactive oxygen species may play a significant role in the adverse effects of IH.
Conclusions:
- Understanding IH patterns is crucial for predicting and mitigating adverse outcomes in preterm infants.
- Oxidative stress pathways warrant further investigation as therapeutic targets for IH-related complications.
- Further research is needed to elucidate the precise mechanisms linking IH patterns to neonatal morbidity.
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