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Increased Gut Permeability in First-degree Relatives of Children with Irritable Bowel Syndrome or Functional
Mark McOmber1, Danny Rafati2, Kevin Cain3
1Department of Pediatrics, Phoenix Children's Hospital, Phoenix, Arizona.
Insights
Siblings and parents of children with irritable bowel syndrome or functional abdominal pain (IBS or FAP) show increased gut permeability. This suggests a familial link to gastrointestinal issues in IBS or FAP.
Area of Science:
- Gastroenterology
- Human Physiology
- Genetics
Background:
- Irritable bowel syndrome or functional abdominal pain (IBS or FAP) may be linked to increased gut permeability.
- Investigating gut permeability in relatives of children with IBS or FAP is crucial for understanding disease pathogenesis.
Purpose of the Study:
- To determine if siblings and parents of children diagnosed with IBS or FAP exhibit heightened gut permeability.
- To explore potential familial influences on gastrointestinal permeability.
Main Methods:
- Employed permeability tests using sucrose, lactulose, mannitol, and sucralose in siblings and parents of children with IBS/FAP and control groups.
- Administered ibuprofen to assess changes in gastroduodenal and small bowel permeability.
- Analyzed urine samples for marker recovery over 24-hour periods.
Main Results:
- Siblings of children with IBS or FAP demonstrated significantly increased small bowel permeability (lactulose/mannitol ratio).
- Parents of children with IBS or FAP also showed elevated small bowel permeability compared to controls.
- No significant differences were observed in gastroduodenal or colonic permeability between groups at baseline.
Conclusions:
- Increased baseline small intestinal permeability is present in both siblings and parents of children with IBS or FAP.
- These findings highlight significant familial contributions to gastrointestinal permeability in IBS/FAP.
Background & Aims:
Increased gut permeability might contribute to the pathogenesis of irritable bowel syndrome or functional abdominal pain (IBS or FAP). We investigated whether siblings and parents of children with IBS or FAP have increased gut permeability.
Methods:
We performed permeability tests (using sucrose, lactulose, mannitol, and sucralose) on 29 siblings and 43 parents of children with IBS or FAP, and 43 children (controls) and 42 parents of controls, from primary and secondary care. Permeability studies were repeated in 7 siblings and 37 parents of children with IBS or FAP and 23 controls and 36 parents of controls following ingestion of 400 mg of ibuprofen. Percent recovery of sucrose was calculated based on analyses of urine collected overnight; the lactulose/mannitol ratio and percent recovery of sucralose were based on analyses of urine samples collected over a 24-hour period.
Results:
When we controlled for age, sex, and family membership, siblings of children with IBS or FAP had increased small bowel permeability (urinary lactulose/mannitol ratio) vs controls (P = .004). There was no difference in gastroduodenal (percent sucrose recovery) or colonic (percent sucralose recovery) permeability between groups. Similarly, parents of children with IBS or FAP also had increased small bowel permeability, compared with parents of controls (P = .015), with no differences in gastric or colonic permeability. After administration of ibuprofen, gastroduodenal and small bowel permeability tended to be greater in IBS or FAP siblings (P = .08) and gastroduodenal permeability tended to be greater in IBS or FAP parents (P = .086).
Conclusions:
Siblings and parents of children with IBS or FAP have increased baseline small intestinal permeability compared with control children and their parents. These results indicate that there are familial influences on gastrointestinal permeability in patients with IBS or FAP.
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