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Updated: Jan 24, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist

Nao Saito1, Keiko Kawase1, Naoya Yamashita1

  • 1Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.

Bioorganic Chemistry
|May 18, 2019
PubMed

Keywords:
Anti-estrogenic activityAnti-proliferative activityBreast cancerEstrogen receptor (ER)Partial agonistSelective estrogen receptor modulators (SERMs)

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