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Long-term growth hormone (GH) replacement of adult GH deficiency (GHD) benefits the heart

A Ziagaki1, D Blaschke2, W Haverkamp2

  • 1Interdisciplinary Centre of Metabolism, Endocrinology, Diabetes and Metabolism.

European Journal of Endocrinology
|May 18, 2019
PubMed

Insights

Long-term growth hormone replacement therapy in growth hormone deficiency patients improved cardiac structure and function. This study observed positive effects on interventricular septum diameter and left ventricular posterior wall diameter, with potential implications for heart remodeling.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Growth hormone deficiency (GHD) is linked to increased cardiovascular mortality.
  • Understanding the impact of growth hormone replacement (GH-R) on cardiovascular health is crucial.

Purpose of the Study:

  • To evaluate the effects of long-term GH-R on clinical status, NT-proBNP levels, and echocardiographic parameters in GHD patients.
  • To identify predictors of cardiovascular outcomes during GH-R therapy.

Main Methods:

  • A cohort of 51 GHD patients (mean age 45.9 years) underwent long-term GH-R with regular echocardiographic and laboratory assessments.
  • Follow-up data was collected at 12-month intervals, with the last observation carried forward (LOCF) for final analysis.

Main Results:

  • GH-R led to a significant decline and stabilization of NT-proBNP levels, particularly in patients with elevated baseline levels.
  • Echocardiography showed significant reductions in LVPWD and IVSD by year three.
  • Left ventricular mass index (LVMi) remained elevated, but showed a correlation with IGF-1 in male patients.

Conclusions:

  • Long-term GH-R positively impacts interventricular septum diameter and left ventricular posterior wall diameter in GHD patients.
  • In severe GHD, increased LVMi correlated with decreased NT-proBNP and higher IGF-1, suggesting potential cardiac remodeling.
  • Further follow-up is needed to determine if these cardiac changes represent beneficial remodeling or a future risk for heart failure.
Abstract

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