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Autologous cord blood in children with cerebral palsy: a review

Dariusz Boruczkowski1, Josep-Maria Pujal2, Izabela Zdolińska-Malinowska3

  • 1Polski Bank Komórek Macierzystych S.A. (FamiCord Group), Jana Pawła II 29, 00-867 Warsaw, Poland. dariusz.boruczkowski@pbkm.pl.

International Journal of Molecular Sciences
|May 19, 2019
PubMed

Insights

Umbilical cord blood (CB) shows promise for diagnosing and treating cerebral palsy. Its biochemical makeup predicts neurodevelopment, and studies confirm the safety and efficacy of CB treatments.

Area of Science:

  • Biomedical Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Cerebral palsy (CP) is a significant neurological disorder.
  • Umbilical cord blood (CB) contains valuable biological components.
  • Current knowledge on CB's clinical applications requires synthesis.

Purpose of the Study:

  • To review current knowledge on the clinical use of umbilical cord blood (CB).
  • To explore CB's potential in early diagnostics and treatment of cerebral palsy.
  • To assess the safety and efficacy of CB administration based on existing studies.

Main Methods:

  • Narrative review of articles from PubMed.
  • Analysis of clinical trials registered on ClinicalTrials.gov.
  • Inclusion of a meta-analysis of five clinical trials.

Main Results:

  • CB's biochemical parameters (cytokines, growth factors, metabolites) predict neurodevelopment.
  • Clinical studies confirm the safety and efficacy of autologous and allogeneic CB administration.
  • Nine ongoing clinical trials are evaluating autologous CB for hypoxic-ischemic encephalopathy and CP in over 2500 patients.

Conclusions:

  • Umbilical cord blood (CB) holds significant potential for cerebral palsy diagnostics and treatment.
  • The biochemical profile of CB is a key indicator for neurodevelopmental outcomes.
  • Ongoing clinical trials are expanding the evidence base for CB therapies in neurological conditions.

Keywords:
HIE, ischemiaasphyxiacellular therapycerebral palsycord bloodhypoxiahypoxic-ischemic encephalopathyperinatal brain injurystem cells

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