Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

9.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Group Therapy01:26

Group Therapy

391
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
391
Psychodynamic Therapy01:29

Psychodynamic Therapy

542
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
542
Humanistic Therapy01:24

Humanistic Therapy

342
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
342

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A classic fold with a twist: Structural architecture of Dhillonvirus phage Bas18.

Journal of molecular biology·2026
Same author

Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle.

Nature communications·2026
Same author

Exploring the role of neutrophils in pathogenesis of lymphangioleiomyomatosis.

Journal of innate immunity·2026
Same author

Epidemiology and Clinical Characteristics of Pulmonary Alveolar Proteinosis in Guangdong, China.

Chest·2026
Same author

Radiation-triggered acute exacerbation of progressive fibrotic interstitial lung diseases: 'Are we advancing the frontier or crossing a dangerous line?'

Therapeutic advances in respiratory disease·2026
Same author

Current insight into molecular mechanisms of Lymphangioleiomyomatosis.

American journal of respiratory cell and molecular biology·2026
Same journal

RETRACTED: Sabir et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. <i>Cancers</i> 2021, <i>13</i>, 3396.

Cancers·2026
Same journal

Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

Cancers·2026
Same journal

Correction: Peñalver et al. Guidelines for Diagnosis, Treatment, and Follow-Up of Patients with Follicular Lymphoma-Spanish Lymphoma Group (GELTAMO) 2026. <i>Cancers</i> 2026, <i>18</i>, 395.

Cancers·2026
Same journal

Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

Cancers·2026
Same journal

Age-Stratified Long-Term Outcomes of Immune Checkpoint Inhibitors for Stage IV Melanoma and NSCLC in The Netherlands: A Population-Based Study.

Cancers·2026
Same journal

Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.

Cancers·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K

Developing Picornaviruses for Cancer Therapy.

Cormac McCarthy1, Nadishka Jayawardena2, Laura N Burga3

  • 1Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand. mccco791@student.otago.ac.nz.

Cancers
|May 19, 2019
PubMed
Summary
This summary is machine-generated.

Picornaviruses are being explored as novel anticancer agents. These oncolytic viruses (OVs) selectively target and destroy cancer cells, offering a promising therapeutic approach.

Keywords:
coxsackievirusoncolytic virotherapypicornaviruspoliovirussenecavirus

More Related Videos

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.0K
Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

481

Related Experiment Videos

Last Updated: Jan 24, 2026

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K
MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.0K
Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

481

Area of Science:

  • Virology
  • Oncology
  • Gene Therapy

Background:

  • Oncolytic viruses (OVs) represent a novel class of anticancer therapeutics.
  • Several viral families, including Picornaviridae, exhibit anticancer properties.
  • Picornaviruses are small, non-enveloped RNA viruses with potential for cancer treatment.

Purpose of the Study:

  • To review picornaviruses investigated for their anticancer potential.
  • To elucidate the mechanisms underlying the cancer-specific activity of picornaviruses.

Main Methods:

  • Literature review of studies on picornaviruses as anticancer agents.
  • Analysis of viral characteristics relevant to cancer therapy.
  • Examination of mechanisms of viral oncolysis and tumor specificity.

Main Results:

  • Picornaviruses demonstrate selective infection and lysis of cancer cells.
  • Advantages for cancer therapy include non-integration of genomes, absence of oncogenes, and ease of genetic manipulation.
  • Specific picornaviruses have been identified and studied for their therapeutic efficacy.

Conclusions:

  • Picornaviruses hold significant promise as oncolytic viruses for cancer treatment.
  • Their inherent biological properties contribute to their specificity and safety profile.
  • Further research into picornavirus mechanisms can optimize their use in oncology.