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Arginine induces IGF-1 secretion from the endoplasmic reticulum
Yoji Tsugawa1, Hiroshi Handa2, Takeshi Imai1
1Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan.
Biochemical and Biophysical Research Communications
|May 19, 2019
Summary
Arginine regulates insulin-like growth factor 1 (IGF-1) secretion by preventing its retention in the endoplasmic reticulum. This discovery reveals a new control system for IGF-1 release, impacting cellular growth and metabolism.
Area of Science:
- Biochemistry
- Cell Biology
- Endocrinology
Background:
- Arginine is a semi-essential amino acid crucial for growth hormone (GH) and insulin-like growth factor 1 (IGF-1) secretion.
- IGF-1, produced by hepatocytes, is vital for cellular metabolism, proliferation, and growth.
- Arginine influences IGF-1 secretion through both GH-dependent and poorly understood arginine-dependent pathways.
Purpose of the Study:
- To elucidate the precise mechanisms governing arginine-dependent IGF-1 secretion.
- To identify the role of arginine concentration in regulating IGF-1 release and cellular processing.
Main Methods:
- Investigated the impact of varying arginine concentrations on IGF-1 levels in fasted mice and cultured hepatocytes.
- Analyzed IGF-1 localization and secretion dynamics within hepatocytes under different arginine conditions.
- Examined the effect of growth hormone (GH) on IGF-1 translation and protein levels.
Main Results:
- Growth hormone (GH) enhances IGF-1 translation and protein levels, promoting secretion.
- Reduced arginine levels lead to the retention of IGF-1 within the endoplasmic reticulum.
- Arginine supplementation effectively reverses IGF-1 retention and restores secretion.
Conclusions:
- A novel mechanism controlling IGF-1 secretion via the endoplasmic reticulum has been identified.
- Arginine plays a critical role in regulating IGF-1 release by modulating its trafficking and secretion from hepatocytes.
- This finding provides new insights into the regulation of cellular growth and metabolism.
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