CLOSTRIDIUM DIFFICILE INFECTION IN CHILDREN WITH EXPOSURE TO ANTIBIOTICS

Clostridium difficile represents an example of healthcare-associated pathogen causing disease in community and hospital setting. The number of clinical studies determining risk factors for Clostridium difficile infection in children is limited as compared to adult patients. The aim of this study was to determine the association between antibiotic exposure in hospital setting and risk of Clostridium difficile infection in children. Systematic review of the electronic databases was used to update the literature, collect secondary data, critically appraise research studies, and synthesize study result from our institutions with available literature. Paper aimed to provide a complete, exhaustive summary of current literature relevant to our research question. A systematic review of the literature using databases PubMed (1935-2018) was conducted to compare our study results with available literature and determine significant differences and similarities that might impact clinical decisions in the country Georgia. The study of the association of several factors with the development of Clostridium difficile infection showed that the age more than 4 years old represented independent risk-factors of the development of Clostridium difficile infection, while the gender and ethnicity was not associated with the infection. Antibiotic exposure within the month preceding the onset of diarrhea was statistically significantly associated with an increased risk of Clostridium difficile infection. The risk was greatest with cephalosporins, followed by penicillins, carbapenems and macrolides. Antibiotic exposure in children is associated with increased risk of Clostridium difficile infections in hospital setting.