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ASSOCIATION BETWEEN URTICARIA AND INFECTIONS (REVIEW)
M Gotua1, B Kulumbegov1, N Chanturidze1
1Center of Allergy and Immunology, Tbilisi, Georgia.
Georgian Medical News
|May 19, 2019
Summary
Chronic urticaria, affecting 20% of people, can significantly impact quality of life. While infections may trigger urticaria, further research is needed to clarify the exact role and management of these infections.
Area of Science:
- Immunology
- Dermatology
- Infectious Diseases
Background:
- Urticaria is a prevalent condition with a substantial impact on patient quality of life and healthcare systems.
- The link between infections and urticaria, particularly chronic spontaneous urticaria (CSU), has been observed, but the underlying mechanisms remain unclear.
- Anecdotal evidence suggests that treating persistent infections can lead to remission of chronic urticaria.
Purpose of the Study:
- To explore the potential role of infections as triggers for urticaria.
- To discuss the pathogenesis of mast cell activation in infectious processes related to urticaria.
- To review the association between chronic viral infections (Hepatitis B and C) and CSU.
Main Methods:
- Literature review on the association between infections and urticaria.
- Discussion of mast cell activation and infectious triggers.
- Analysis of reported cases of CSU remission after infection treatment.
Main Results:
- Chronic viral infections like Hepatitis B and C have been linked to CSU.
- Successful treatment of persistent infections has been associated with remission of chronic urticaria.
- The precise role and pathogenesis of mast cell activation by infections in urticaria are not fully understood.
Conclusions:
- More research is required to establish definitive recommendations for managing infections in patients with urticaria and urticarial vasculitis.
- Routine screening for all infections in chronic urticaria is not advised.
- Physicians may consider infection testing based on individual patient factors such as symptoms, history, and clinical presentation.
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