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Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
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[PECULIARITIES OF THE PREVALENCE OF POLYMORPHISM (C-589T) OF THE IL-4 GENE AND ITS RELATIONSHIP WITH SERUM IL-4 LEVEL
E Huseynov1, L Moroz2, O Androsova2
11Azerbaijan Medical University, Baku, Republic of Azerbaijan.
Abstract:
The aim of the study was to determine the frequency of polymorphism of IL-4 (C-589T) in patients with acute brucellosis in the Republic of Azerbaijan and to establish its correlation with serum IL-4 levels. One hundred seventy eight patients with clinical symptoms of brucellosis were examined. According to the criteria for inclusion in a study of 178 patients, only 120 persons- (the main group) - fully met all criteria. The control group consisted of 30 practically healthy persons. Also, all patients in both groups were tested for IL-4 (C-589T) polymorphism and level of interleukin-4 (IL-4). It has been established that carriers of the allele T of the polymorphic (C-589T) IL-4 gene are at increased risk for brucellosis (OR=4.26, 95% CI [2.01-9.05]], whereas in the case of carrier allele C, on the contrary, is a reduced risk of developing brucellosis. The combination of genotypes C/T + T/T among patients with brucellosis was determined 3.1 times more than in practically healthy individuals (OR=10.31, 95% CI [1.55-19.18], χ2=29.21, p<0.0001). It was found that among the carriers of the C/C genotype, IL-4 level was 1.44 higher in brucellosis than in T/T genotype carriers and 1.2 times higher in comparison with the C/T genotype. Among carriers of the C/T genotype, there is a significantly increased risk of brucellosis (χ2=29.73; p=4.0E-7; OR=9.63; 95% CI [3.43-27.03] while cariousness of the homozygous genotype C/С, on the contrary, has a protective effect on the development of brucellosis (OR=0.10, 95% CI 0.04-0.25).
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