[STRUCTURAL, MOLECULAR AND FUNCTIONAL FEATURES OF THE TREMATODE TEGUMENT AND OF ANTHELMINTIC DRUGS DEVELOPMENT
S Larina1, N Burdaev1, I Berechikidze1
1The First Moscow State Medical University. I.M. Sechenov, Russia.
Abstract:
Helminth infestations, including trematodoses, are a group of the most common diseases in the world. Trematodoses cause significant damage to human health, lead to various complications, which also causes significant economic damage. To develop effective anthelmintic drugs, it is necessary to study the structure and physiology of parasites and interaction with the host body. To create specific anthelmintic drugs, it is necessary to study the features of biochemistry and molecular biology of the structural components of the covers of trematodes. The is important role of the tegument in the evasion of the immune response. The trematode tegument antigens are good candidates for the development of anthelmintic vaccines. It is important to study the trematode genome and identify specific enzyme systems. Proteases of tegument of trematodes are digestive enzymes that can destroy the immunoglobulins of the host to modulate the immune response. Identification of specific differences in protein and enzyme systems will create more effective drugs for the treatment of helminthiasis.
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