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Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Related Experiment Video

Updated: Jan 24, 2026

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
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Publisher Correction: Lysosomal storage diseases.

Frances M Platt1, Alessandra d'Azzo2, Beverly L Davidson3,4

  • 1Department of Pharmacology, University of Oxford, Oxford, UK. frances.platt@pharm.ox.ac.uk.

Nature Reviews. Disease Primers
|May 19, 2019
PubMed
Summary

Figure 3 has been corrected to accurately link APP to CMA, include NCP2 labels, and correctly identify GlcSph as GlcCer. These scientific figure corrections ensure data integrity and accurate representation of molecular relationships.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Context:

  • The original publication contained errors in Figure 3, specifically regarding molecular linkages and labels.
  • Accurate representation of molecular interactions is crucial for scientific understanding.

Purpose:

  • To correct inaccuracies in Figure 3 of the original publication.
  • To ensure the figure accurately depicts the relationships between APP, CMA, NCP2, GlcSph, and GlcCer.

Summary:

  • The corrected Figure 3 now accurately links Amyloid Precursor Protein (APP) to Cathepsin (CMA).
  • The label for Neurocan (NCP2) has been added.
  • Galactosylceramide (GlcSph) is now correctly identified, distinguishing it from Glucosylceramide (GlcCer).

Impact:

  • Ensures accurate data representation in the scientific record.
  • Facilitates correct interpretation of molecular pathways involving APP and related lipids.
  • Improves the reliability of future research referencing this figure.