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Updated: Jan 24, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
Published on: December 1, 2023
Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience
M Lloret1,2,3, L García-Cabrera4, A Hernandez4
1Department of Radiation Oncology, Dr. Negrin Hospital, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. mllosae@gobiernodecanarias.org.
Background:
Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.
Methods:
Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.
Results:
Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.
Conclusions:
Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.
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