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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
Published on: May 19, 2020
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The Role of Complement C3a Receptor in Stroke.
Saif Ahmad1, Kanchan Bhatia2,3, Adam Kindelin2
1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center (SJHMC), Dignity Health, 350 W Thomas Rd, Phoenix, AZ, 85013, USA. saif.ahmad@barrowneuro.org.
Neuromolecular Medicine
|May 19, 2019
Summary
The complement system
Area of Science:
- Immunology and neuroscience, focusing on the complement system's role in innate immunity and neurological diseases.
Background:
- The complement system regulates immune responses and its dysregulation contributes to neurological diseases like stroke.
- C3a anaphylatoxin and its receptor (C3aR) mediate inflammation, blood-brain barrier breakdown, and leukocyte infiltration in ischemic brain.
Purpose of the Study:
- To investigate the role of the C3a receptor (C3aR) in brain ischemia.
- To explore C3aR as a therapeutic target for stroke.
Main Methods:
- Utilizing complement-deficient mice and pharmacologic C3aR antagonists in experimental stroke models.
- Proposing the development of tissue-specific C3aR knockout mice for detailed study.
Main Results:
- Studies show reduced tissue injury and mortality in murine stroke models using complement deficiency or C3aR antagonists.
- Evidence suggests C3aR signaling exacerbates damage in experimental stroke.
Conclusions:
- The C3a receptor (C3aR) plays a significant role in the inflammatory response and tissue damage following stroke.
- Targeting C3aR presents a promising therapeutic strategy for clinical translation in stroke patients.
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