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Related Experiment Video

Updated: Jan 24, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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CTHRC1 expression in primary biliary cholangitis.

Yi Kang Li1, Yan Mei Li1, You Li1

  • 1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes; Shanghai Institute of Digestive Disease; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Journal of Digestive Diseases
|May 19, 2019
PubMed
Summary
This summary is machine-generated.

Collagen triple helix repeat containing-1 (CTHRC1) is elevated in cholestatic liver diseases, correlating with fibrosis and inflammation. Serum CTHRC1 may serve as a noninvasive biomarker for assessing liver conditions.

Keywords:
cholestasiscollagen triple helix repeat containing-1fibrosisprimary biliary cholangitis

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Area of Science:

  • Hepatology
  • Biochemistry
  • Immunology

Background:

  • Collagen triple helix repeat containing-1 (CTHRC1) is an extracellular matrix glycoprotein.
  • CTHRC1 is overexpressed in murine models of cholestatic liver fibrosis.
  • Elevated CTHRC1 has been shown to attenuate liver fibrosis in these models.

Purpose of the Study:

  • To investigate CTHRC1 expression in human cholestatic liver diseases.
  • To determine the correlation between CTHRC1 and hepatic conditions in patients.

Main Methods:

  • Immunohistochemistry was used to analyze liver sections from 90 patients (primary biliary cholangitis, primary sclerosing cholangitis, chronic hepatitis B) and 5 healthy controls.
  • Enzyme-linked immunosorbent assay detected serum CTHRC1 levels in 59 primary biliary cholangitis patients and 10 healthy controls.

Main Results:

  • CTHRC1 protein was mainly expressed in activated hepatic stellate cells.
  • CTHRC1 expression was significantly higher in primary biliary cholangitis and primary sclerosing cholangitis groups compared to healthy controls and chronic hepatitis B groups.
  • Hepatic fibrosis stage in primary biliary cholangitis patients positively correlated with hepatic CTHRC1 expression (r = 0.425, P = 0.003).
  • Serum CTHRC1 levels correlated with hepatic inflammation and fibrosis stage in primary biliary cholangitis patients (r = 0.300, P = 0.022; r = 0.321, P = 0.012).

Conclusions:

  • CTHRC1 may contribute to hepatic fibrogenesis in primary biliary cholangitis.
  • Serum CTHRC1 shows potential as a novel noninvasive biomarker for assessing liver fibrosis and inflammation.