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Advances in the relationship between glycosyltransferases and multidrug resistance in cancer

Yinshuang Wu1, Xixi Chen2, Shidan Wang1

  • 1Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, Liaoning, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 19, 2019
PubMed

Insights

Glycosyltransferases (GTs) are linked to cancer progression and multidrug resistance (MDR). Understanding GTs

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Cancer remains a significant global health challenge, causing substantial morbidity and mortality.
  • Multidrug resistance (MDR) in chemotherapy is a major obstacle to effective cancer treatment.
  • Aberrant glycosylation, often due to abnormal glycosyltransferase (GT) expression, is a hallmark of cancer.

Purpose of the Study:

  • To review the role of glycosyltransferases (GTs) in mediating multidrug resistance (MDR) in various cancer types.
  • To summarize existing research on the correlation between GTs and MDR in cancer cells.
  • To explore the complex mechanisms by which GTs influence therapeutic outcomes in cancer treatment.

Main Methods:

  • Systematic literature review of studies investigating glycosyltransferases (GTs) and multidrug resistance (MDR).
  • Analysis of research focusing on the association between GTs, aberrant glycosylation, and cancer progression.
  • Examination of studies detailing the mechanisms of GT involvement in MDR.

Main Results:

  • Abnormal expression of GTs is frequently observed in cancer and linked to aberrant glycosylation patterns.
  • GTs play a crucial role in the development and maintenance of MDR in cancer cells.
  • The activity of GTs can significantly impact the efficacy of chemotherapy and overall therapeutic effect.

Conclusions:

  • Glycosyltransferases (GTs) are implicated as key players in cancer multidrug resistance (MDR).
  • Targeting GTs may offer novel strategies to overcome MDR and improve cancer treatment outcomes.
  • Further research into GTs and their mechanisms in cancer is warranted for therapeutic advancements.
Keywords:
CancersGlycosylationGlycosyltransferasesMDR

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