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Potential benefits of using a multicomponent vaccine for prevention of serogroup B meningococcal disease

Philip S Watson1, Patricia L Novy2, Leonard R Friedland2

  • 1GSK, Rockville, MD, USA.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|May 19, 2019
PubMed

Insights

Meningococcal serogroup B (MenB) vaccines, like 4CMenB, offer broad protection against invasive MenB disease. This multicomponent vaccine may also protect against other meningococcal strains and gonorrhea.

Area of Science:

  • Microbiology
  • Immunology
  • Vaccinology

Background:

  • Meningococcal serogroup B (MenB) is a leading cause of invasive meningococcal disease in industrialized nations.
  • MenB vaccine development is challenging due to strain diversity and poor immunogenicity of the MenB capsular polysaccharide.
  • Two MenB vaccines utilizing factor H binding protein (fHbp) are now available.

Purpose of the Study:

  • To evaluate the effectiveness of the multicomponent 4CMenB vaccine against Meningococcal serogroup B (MenB) disease.
  • To assess the potential of 4CMenB to provide cross-protection against non-MenB meningococci and Neisseria gonorrhoeae.

Main Methods:

  • Analysis of circulating MenB strains for vaccine antigen gene content.
  • Review of studies on serum bactericidal activity against strains expressing multiple vaccine antigens.
  • Evaluation of available data on 4CMenB effectiveness.

Main Results:

  • Most circulating MenB strains possess genes for at least one 4CMenB component, with many expressing multiple antigens.
  • Serum bactericidal activity may be enhanced when antibodies to multiple vaccine components are present.
  • 4CMenB demonstrates broad coverage and protection against MenB disease.

Conclusions:

  • The multicomponent 4CMenB vaccine provides broad protection against MenB disease.
  • Cooperative antibody activity against multiple vaccine components may enhance bacterial killing.
  • 4CMenB shows potential for cross-protection against other meningococcal serogroups and Neisseria gonorrhoeae.
Keywords:
4CMenBCross-protectionMeningococcal serogroup BMulticomponent vaccine

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