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Related Experiment Video

Updated: Jan 24, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
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Immune function testing in sepsis patients receiving sodium selenite.

Anne Guo1, Jyotsna Srinath2, Matthias Feuerecker1

  • 1Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

Journal of Critical Care
|May 19, 2019
PubMed
Summary

Sodium selenite did not improve immune response in sepsis patients. Blood samples showed no difference in cytokine release between selenium and placebo groups, suggesting a reason for selenium

Keywords:
CytokinesImmune functionSeleniumSepsis

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Area of Science:

  • Immunology
  • Clinical Medicine
  • Nutritional Science

Background:

  • Selenium is a trace element crucial for immune function.
  • Selenium supplementation has been explored as an adjuvant therapy for sepsis.
  • Recent studies question selenium's benefit on sepsis mortality outcomes.

Purpose of the Study:

  • To investigate the effect of sodium selenite on immune performance in sepsis patients.
  • To assess immune response by measuring cytokine concentrations in whole blood samples.
  • To evaluate selenium's role in strengthening immune function during sepsis.

Main Methods:

  • Longitudinal study analyzing whole blood samples from sepsis patients.
  • Immune functional assays measuring cytokine release after antigen stimulation.
  • Statistical analysis using a generalized least squares model on longitudinal data.

Main Results:

  • No statistically significant difference in immune response between selenium and placebo groups.
  • Overall dampening of cytokine release observed in both groups.
  • Cytokine release showed a tendency to recover over time in both treatment arms.

Conclusions:

  • Sodium selenite therapy did not enhance immune cell cytokine release ex vivo in sepsis patients.
  • This finding may explain the lack of beneficial effects of selenium on sepsis mortality.
  • Selenium's role as an adjuvant therapy in sepsis requires further investigation.