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Overgrowth Syndrome.

Yahan Li¹, Callum G Donnelly², Rocío Melissa Rivera¹

¹Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.

The Veterinary Clinics of North America. Food Animal Practice

|May 20, 2019

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Large offspring syndrome (LOS) in cattle, often linked to assisted reproductive technologies (ART), may also occur spontaneously (S-LOS). This study proposes that both forms of fetal overgrowth are caused by a loss-of-imprinting epigenetic condition.

Area of Science:

Reproductive biology
Epigenetics
Veterinary medicine

Background:

Large offspring syndrome (LOS) is a fetal overgrowth condition in cattle, frequently associated with assisted reproductive technologies (ART).
LOS phenotypes include overgrowth, enlarged tongues, umbilical hernias, and skeletal malformations.
Spontaneous fetal overgrowth in cattle (S-LOS) occurs without ART and results in oversized calves born at normal gestation.

Keywords:

Abnormal offspring syndrome Assisted reproduction Large offspring syndrome Overgrowth Spontaneous LOS

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