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Novel Myocardial PET/CT Receptor Imaging and Potential Therapeutic Targets

Ines Valenta1, Pal Pacher2, Vasken Dilsizian3

  • 1Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Washington University School of Medicine, Washington University in St. Louis, 510 S. Kingshighway Boulevard, Campus Box 8223, St. Louis, MO, 63110, USA.

Current Cardiology Reports
|May 20, 2019
PubMed
Abstract

Insights

Novel imaging techniques using positron emission tomography (PET) can noninvasively assess cannabinoid type 1 receptors (CB1-R) and angiotensin II type 1 receptors (AT1-R) in heart failure. This aids in understanding left-ventricular remodeling and tailoring patient care.

Area of Science:

  • Cardiovascular imaging
  • Molecular imaging
  • Radiochemistry

Background:

  • Myocardial cannabinoid type 1 receptors (CB1-R) and angiotensin II type 1 receptors (AT1-R) activation are implicated in left-ventricular remodeling in systolic heart failure.
  • Understanding these receptor expressions is crucial for developing targeted therapies.

Purpose of the Study:

  • To review novel radiotracer probes and PET/CT imaging techniques for noninvasively assessing myocardial CB1-R and AT1-R expression.
  • To highlight the role of these receptors in systolic heart failure and the potential of PET imaging.

Main Methods:

  • Utilizing positron emission tomography (PET) combined with computed tomography (CT) for imaging.
  • Employing specific radiotracer probes like 11C-OMAR for CB1-R and 11C-KR31173 for AT1-R.

Main Results:

  • Demonstrated feasibility of PET/CT with 11C-OMAR and 11C-KR31173 to image and quantify myocardial CB1-R and AT1-R expression.
  • Growing understanding of how activated CB1-R and AT1-R influence left-ventricular remodeling in various heart failure conditions.

Conclusions:

  • PET imaging of myocardial CB1-R and AT1-R expression offers a noninvasive approach to assess heart failure mechanisms.
  • This imaging modality holds potential for personalized preventive medical care in heart failure patients.
Keywords:
Angiotensin II type 1 receptorsAngiotensin-converting enzymeCannabinoid type 1 receptorHeart failureLeft-ventricular remodelingObesityPositron emission tomography

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