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Circulating lectin pathway proteins do not predict short-term cardiac outcomes after myocardial infarction

C B Holt1,2,3, J A Østergaard1,4, S Thiel2

  • 1Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.

Clinical and Experimental Immunology
|May 20, 2019
PubMed

Insights

Plasma levels of lectin pathway proteins and soluble membrane attack complex do not predict short-term cardiac outcomes after myocardial infarction (MI). C-reactive protein (CRP) showed a negative correlation with left ventricular ejection fraction (LVEF).

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Coronary artery disease remains a leading global cause of death, with myocardial infarction (MI) and stroke being primary contributors.
  • Inflammation, particularly the complement system, plays a role in the pathogenesis of reperfusion injury following MI.
  • New therapeutic strategies targeting inflammation are crucial for managing MI patients.

Purpose of the Study:

  • To investigate the association between plasma levels of lectin pathway proteins and myocardial endpoints (left ventricular ejection fraction and infarct size) in ST-elevation myocardial infarction (STEMI) patients.
  • To determine if lectin pathway proteins or soluble membrane attack complex (sMAC) can predict short-term cardiac outcomes after STEMI.

Main Methods:

  • Plasma samples were collected from 73 STEMI patients post-percutaneous coronary intervention.
  • Lectin pathway proteins (mannan-binding lectin, H-ficolin, L-ficolin, M-ficolin), sMAC, and C-reactive protein (CRP) were quantified using immunofluorometric assays.
  • Left ventricular ejection fraction (LVEF) and infarct size were assessed via cardiac magnetic resonance imaging 6-9 days post-MI.

Main Results:

  • C-reactive protein (CRP) showed a significant negative correlation with LVEF (regression coefficient = -0.17, P = 0.01).
  • No significant correlations were found between plasma levels of lectin pathway proteins or sMAC and LVEF or infarct size.
  • Plasma levels of these complement components did not differ between patients with LVEF <50% and those with LVEF ≥50%.

Conclusions:

  • Pattern-recognition molecules of the lectin complement pathway and sMAC do not serve as predictors of short-term cardiac outcomes in patients with ST-elevation myocardial infarction.
  • While CRP correlates with cardiac function post-MI, the lectin pathway does not appear to influence short-term myocardial recovery in this cohort.

Keywords:
complement systemischaemia/reperfusion injurylectin pathwaymyocardial infarction

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