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Updated: Jan 24, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
Published on: July 15, 2009
Strontium-incorporated titanium implant surface treated by hydrothermal reactions promotes early bone
Guofen Lin1, Chuan Zhou2, Mengna Lin2
1Department of General Dentistry, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Objectives:
The aim of the present study was to investigate the effects of strontium-modified implant surfaces on promoting early bone osseointegration in osteoporotic rabbits.
Materials And Methods:
The surface topographies, chemical elements, contact angles and ionic releases of the SLA and SLA-Sr samples were analysed by special instruments separately. Sixteen ovariectomized New Zealand rabbits received glucocorticoid administration, and sixteen SHAM rabbits were used as controls. After generating a successful osteoporosis-induced model, SLA and SLA-Sr implants were randomly inserted into the tibia and femur metaphysis of each animal. The rabbits were sacrificed after 3 and 6 weeks of bone healing, and then, removal torque values (RTVs), percentage of bone area (BA%) and percentage of bone-to-implant contact (BIC%) were analysed for the SLA-Sr and SLA implants.
Results:
Multiple nanostructures were found on the Sr-incorporated titanium surface, and appropriate amounts of strontium ions from the SLA-Sr surface were released into the surrounding tissue within 21 days. In vivo, SLA-Sr implants displayed much more new bone around their surfaces than the SLA implants. Significantly higher RTVs and BIC% were observed for the SLA-Sr implants than for the SLA implants in both osteoporotic (p < 0.01) and healthy animals (p < 0.01) at 3 and 6 weeks. The SLA-Sr implants exhibited higher BA% in cortical bone (p < 0.01) and in cancellous bone (p < 0.05) than the SLA implants in osteoporotic rabbits at 3 weeks.
Conclusions:
It is suggested that Sr-incorporated surfaces treated through hydrothermal reactions have positive effects on promoting early osseointegration in both osteoporotic and non-osteoporotic rabbits.
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