Related Experiment Video

Updated: Jan 24, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

6.1K

Investigating macrophage-mediated inflammation in migraine using ultrasmall superparamagnetic iron oxide-enhanced 3T

Sabrina Khan1, Faisal Mohammad Amin1, Frederikke Petrine Fliedner2

  • 1Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.

Cephalalgia : an International Journal of Headache
|May 21, 2019
PubMed
Abstract

Insights

This study investigated macrophage-mediated inflammation as a potential migraine biomarker. Researchers found no evidence of such inflammation on the head pain side in patients with migraine without aura.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Inflammation Research

Background:

  • Migraine headache mechanisms are poorly understood, and no reliable biomarker exists.
  • Cerebral artery and brain parenchyma inflammation is a suspected factor in migraine pathophysiology.

Purpose of the Study:

  • To conduct the first human study investigating macrophage-mediated inflammation as a potential migraine biomarker.
  • To explore the role of inflammation in migraine pathophysiology using advanced imaging techniques.

Main Methods:

  • Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced 3T MRI was used to detect macrophages in cerebral arteries and brain parenchyma.
  • Migraine without aura patients underwent MRI before and after cilostazol-induced migraine attacks.
  • A preclinical mouse model was used to validate USPIO-enhanced MRI for detecting macrophage-mediated inflammation.

Main Results:

  • USPIO-enhanced MRI confirmed macrophage detection in a preclinical model.
  • In human patients, migraine attacks were not linked to increased USPIO signal on the head's pain side.
  • No significant difference in USPIO signal was observed between the pain and non-pain sides during migraine attacks.

Conclusions:

  • Migraine without aura is not associated with macrophage-mediated inflammation on the head pain side.
  • The study did not identify macrophage-mediated inflammation as a biomarker for migraine without aura.
Keywords:
HeadacheUSPIOdura materferumoxytolinflammationmeningeal nociceptor

More Related Videos

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

12.6K
Fabrication of a Functionalized Magnetic Bacterial Nanocellulose with Iron Oxide Nanoparticles08:59

Fabrication of a Functionalized Magnetic Bacterial Nanocellulose with Iron Oxide Nanoparticles

Published on: May 26, 2016

13.8K

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
9.2K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
237
Inflammation01:38

Inflammation

Overview
61.9K
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
1.2K
Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
6.8K
Resonance02:52

Resonance

The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
64.8K