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Updated: Jan 24, 2026
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Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
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Liver Procurement from Poisoned Donors: A Survival Study
Meysam Mojtabaee1, Fariba Ghorbani, Saman Nikeghbalian
1From the Organ Procurement Unit, Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Summary
Livers from poisoned donors can be safely used for liver transplantation, showing similar survival rates to those from trauma donors. This finding supports expanding donor criteria to reduce liver transplant mortality.
Area of Science:
- Transplantation Medicine
- Hepatology
- Organ Donation
Background:
- Donor characteristics significantly impact liver transplant outcomes.
- Limited research exists on the quality and outcomes of livers from poisoned donors.
Purpose of the Study:
- To compare the quality and transplant outcomes of livers from poisoned donors versus a matched control group of trauma-induced death donors.
Main Methods:
- A retrospective analysis of liver transplant data from 2000-2013.
- Evaluation of procured livers via histology.
- Comparison of recipient characteristics and survival rates (immediate to 5-year) using Kaplan-Meier analyses and log-rank tests.
Main Results:
- 74 liver transplants were performed using grafts from 115 evaluated poisoned donors.
- Poisoned donors experienced a 54.1% incidence of reversed cardiac arrest.
- No significant differences in 1- to 5-year survival rates were observed between poisoned and trauma donor groups (p=0.83).
Conclusions:
- Poisoned donors can be a viable source to expand the liver donor pool.
- Poisoning should not be an automatic contraindication for donor referral.
- Utilizing poisoned donors can potentially decrease mortality rates for liver transplant candidates.
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