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Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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Chimeric antigen receptor-engineered regulatory T lymphocytes: promise for immunotherapy of autoimmune disease

Li Yi1, Yin Weifan2, Yang Huan1

  • 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Cytotherapy
|May 21, 2019
PubMed

Regulatory T lymphocytes (Tregs) exist as natural ideal immunosuppressors in the immune system. Autologous or allogeneic Treg transfusion therapy has been carried out in animal models and humans as a new strategy for treating autoimmune disease. Recent studies have shown that Tregs can be engineered with chimeric antigen receptors to be antigen-specific, which are more effective than polyclonal Tregs with fewer target limitations and a lack of major histocompatibility complex restriction. This review describes the potential for applying chimeric antigen receptor-engineered regulatory T cells in autoimmune diseases.

Keywords:
autoimmune diseaseschimeric antigen receptorregulatory T lymphocytestreatment

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