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Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery

Silvia Muro1,2,3

  • 1Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. smuro@ibecbarcelona.eu.

Biomimetics (Basel, Switzerland)
|May 21, 2019
PubMed

Insights

Endocytosis and vesicular transport are key for drug delivery, but factors like disease, drugs, and poor models can hinder their effectiveness. Optimizing these cellular routes is crucial for therapeutic success.

Area of Science:

  • Cell Biology
  • Pharmacology
  • Biotechnology

Background:

  • Endocytosis and vesicular trafficking are fundamental cellular processes essential for life.
  • These processes are critical targets for improving therapeutic drug delivery across biological barriers and into diseased cells.

Purpose of the Study:

  • To critically review the use of endocytosis and vesicular transport for drug delivery.
  • To discuss current achievements, limitations, and future perspectives in this field.
  • To highlight the impact of various factors on the efficacy of vesicular transport for drug delivery.

Main Methods:

  • Literature review of endocytosis and vesicular transport mechanisms in drug delivery.
  • Analysis of factors affecting vesicular transport, including disease pathology, drug activity, and drug carriers.
  • Evaluation of current cellular models and their physiological relevance.

Main Results:

  • Vesicular transport offers significant translational potential for drug delivery.
  • Numerous factors, often overlooked, can alter vesicular transport routes, impacting drug efficacy.
  • Existing cellular models frequently lack physiological relevance, impeding translational progress.

Conclusions:

  • Altered vesicular transport, due to disease, drugs, or carriers, presents a major challenge.
  • Improved cellular models reflecting physiological parameters are needed for advancing drug delivery.
  • Further research is essential to overcome limitations and harness the full potential of vesicular transport in therapeutics.
Keywords:
cellular vesiclesdisease effects on vesicular traffickingdrug delivery systems and nanomedicinesdrug effects on vesicular traffickingfission and intracellular traffickingrole of the biological environmenttranscytosis and endocytosis of drugs carriersvesicle fusion

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