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Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors

Yongjun Sun1,2, Xue Feng3, Yue Ding4

  • 1Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, China.

Frontiers in Cellular Neuroscience
|May 21, 2019
PubMed

Insights

Glutamate receptor antagonists show promise for treating cerebral ischemia by targeting excitotoxicity. This review proposes phased treatment strategies for acute and post-acute phases to reduce neuronal injury.

Area of Science:

  • Neuroscience
  • Neurology
  • Pharmacology

Background:

  • Cerebral ischemia causes extracellular glutamate buildup, leading to excitotoxicity and neuronal damage via glutamate receptor overactivation.
  • Existing therapeutic strategies targeting glutamate receptor function have not yielded clinical success.

Purpose of the Study:

  • To review the roles of ionotropic and metabotropic glutamate receptors in cerebral ischemia.
  • To propose phased treatment strategies for managing cerebral ischemia based on glutamate receptor activity.

Main Methods:

  • Comprehensive literature review of studies on glutamate receptors in cerebral ischemia.
  • Analysis of evidence for glutamate receptor involvement in acute and post-acute ischemic phases.

Main Results:

  • Detailed examination of the functions of various ionotropic and metabotropic glutamate receptors during cerebral ischemia.
  • Identification of potential therapeutic windows for glutamate receptor antagonist application.

Conclusions:

  • Glutamate receptors play a critical role in excitotoxic neuronal injury following cerebral ischemia.
  • Phased treatment strategies targeting glutamate receptors may offer a viable therapeutic approach for clinical application.
Keywords:
cerebral ischemiaexcitotoxicityglutamate receptor antagonistglutamate receptorsphased treatment strategies

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