Influence of caffeine on mitomycin C induced mutagenesis: a simple explanation

It has recently been suggested that caffeine probably represses mutations induced by mitomycin C by selectively killing cells with damaged DNA resulting from inhibition of an error-prone repair process which fails to be completed. A more likely explanation is that caffeine exerts its inhibitory effects on mitomycin C mutagenesis because of its well-documented ability to inhibit urvA.B.C-dependent excision repair.