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The Interplay Between Lymphatic Vessels and Chemokines
Rae H Farnsworth1,2, Tara Karnezis3, Simon J Maciburko3
1Tumor Angiogenesis and Microenvironment Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Frontiers in Immunology
|May 21, 2019
Summary
Chemokines guide immune cell movement through blood and lymphatic vessels. This review explores their roles in cell migration, lymphatic vessel remodeling, and disease pathogenesis.
Area of Science:
- Immunology
- Cell Biology
- Vascular Biology
Background:
- Chemokines are cytokines that direct cell migration, crucial for immune surveillance and inflammation.
- Leukocyte extravasation into tissues is a primary cell recruitment mechanism.
- Lymphatic vessels also facilitate cell trafficking, influenced by chemokine gradients.
Purpose of the Study:
- To review the multifaceted roles of chemokines and their receptors.
- To elucidate chemokine involvement in lymphatic vessel dynamics.
- To understand chemokine-mediated interactions in health and disease.
Main Methods:
- Literature review of chemokine function and receptor expression.
- Analysis of chemokine roles in immune cell trafficking.
- Examination of chemokine impact on lymphatic endothelial cells (LECs).
Main Results:
- Chemokines regulate both homeostatic and inflammatory cell migration.
- Lymphatic vessels are key conduits for cell recruitment, modulated by chemokines.
- Chemokines and their receptors influence lymphatic vessel growth and remodeling in pathology.
Conclusions:
- Chemokines are pivotal in orchestrating immune cell and pathological cell interactions.
- Understanding chemokine-lymphatic vessel crosstalk is vital for disease insights.
- Targeting chemokine pathways may offer therapeutic strategies for inflammatory diseases.
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