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Evaluation of hemodynamics in patients with hypertrophic cardiomyopathy by vector flow mapping: Comparison with

Yuan Cao1, Xiao-Yan Sun2, Ming Zhong1

  • 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

Experimental and Therapeutic Medicine
|May 21, 2019
PubMed

Insights

Vector Flow Mapping (VFM) reveals reduced energy loss (EL) in hypertrophic cardiomyopathy (HCM) patients, indicating subclinical left ventricular (LV) dysfunction. This blood flow analysis quantifies intra-LV and left atrial efficiency.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition affecting left ventricular (LV) function.
  • Assessing subclinical LV dysfunction in HCM is crucial for early diagnosis and management.
  • Vector Flow Mapping (VFM) offers a novel approach to analyze intra-cardiac blood flow dynamics.

Purpose of the Study:

  • To investigate the role of energy loss (EL) measured by VFM in patients with HCM.
  • To evaluate VFM as a tool for detecting subclinical left ventricular dysfunction in HCM.
  • To compare intra-LV and left atrial blood flow energy loss between HCM patients and controls.

Main Methods:

  • VFM analysis was performed on 42 HCM patients and 40 matched controls.
  • Intra-LV and left atrial blood flow were assessed from the apical 3-chamber view.
  • Energy loss (EL) was calculated during systolic and diastolic phases, averaged over three cardiac cycles, and indexed to body surface area.

Main Results:

  • Patients with HCM showed significantly decreased diastolic left ventricular energy loss (LVEL) compared to controls (P<0.05).
  • Left atrial energy loss (LAEL) was significantly lower in HCM patients across all phases (P<0.01).
  • A trend towards increased systolic LVEL was observed in HCM patients, while LVEL-mid was higher during systolic P5.

Conclusions:

  • Measurement of energy loss by VFM is a sensitive method for detecting subclinical LV dysfunction in HCM.
  • EL serves as a quantitative parameter for estimating intraventricular blood flow efficiency.
  • VFM analysis provides valuable insights into altered hemodynamics in hypertrophic cardiomyopathy.

Keywords:
echocardiographyenergy losshypertrophic cardiomyopathyvector flow mapping

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