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Updated: Jan 24, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases
Xiaoying Hu1, Shucan Ma1, Caixia Yang1
1The First Department of Geriatric Medicine, Harrison International Peace Hospital, Hengshui, Hebei 053000, P.R. China.
Insights
Senile osteoporosis is closely linked to cardiovascular diseases like hypertension, coronary heart disease, and cerebral infarction in the elderly. Early osteoporosis screening may help predict these conditions.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Bone Metabolism
Background:
- Senile osteoporosis is a growing concern in elderly populations.
- Cardiovascular diseases, including hypertension, coronary heart disease, and cerebral infarction, are prevalent among the elderly.
- The potential relationship between osteoporosis and these cardiovascular conditions requires further investigation.
Purpose of the Study:
- To investigate the relationship between senile osteoporosis and cardiovascular diseases such as hypertension, coronary heart disease, and cerebral infarction.
- To analyze risk factors for osteoporosis in the elderly.
- To determine the incidence of osteoporosis in relation to the severity of cardiovascular conditions.
Main Methods:
- A retrospective study involving 428 elderly patients was conducted.
- Patients were categorized based on bone density measurements (osteoporosis vs. non-osteoporosis group).
- Incidence of osteoporosis was analyzed across different severities of hypertension, coronary heart disease (vessel disease), and cerebral infarction.
Main Results:
- Hypertension, coronary heart disease, and cerebral infarction were identified as major risk factors for osteoporosis in the elderly.
- Osteoporosis incidence increased significantly with the severity of coronary heart disease (three-vessel disease > double-vessel disease > single-vessel disease).
- Higher incidences of osteoporosis were observed in moderate and severe hypertension and cerebral infarction groups compared to mild cases, with significant differences between severity levels.
Conclusions:
- A close correlation exists between senile osteoporosis and hypertension, coronary heart disease, and cerebral infarction.
- Osteoporosis may serve as an early predictor for screening hypertension, coronary heart disease, and cerebral infarction in the elderly.
- Further research into the underlying mechanisms connecting osteoporosis and cardiovascular health is warranted.
Abstract:
The relationship between senile osteoporosis and cardiovascular hypertension, coronary heart disease and cerebral infarction was investigated. A retrospective study on 428 elderly patients hospitalized in Harrison International Peace Hospital from June 2014 to January 2017 was conducted. There were 207 cases of coronary heart disease, 102 cases of hypertension and 119 cases of cerebral infarction. According to bone density measurement results, the subjects were divided into the osteoporosis group and the non-osteoporosis group. Risk factors for osteoporosis were analyzed, and the incidence of osteoporosis in hypertension, coronary heart disease, and cerebral infarction populations of different severity was analyzed. Hypertension, coronary heart disease and cerebral infarction were the main risk factors for osteoporosis in the elderly. Incidence of osteoporosis in the double-vessel disease group and the three-vessel disease group was significantly higher than that in the single-vessel disease group. Incidence of osteoporosis was significantly higher in the three-vessel disease group than that in the double-vessel disease group (P<0.05). Incidence of osteoporosis was significantly higher in the moderate hypertension and severe hypertension groups than that in the mild hypertension group. Incidence of osteoporosis was significantly higher in patients with severe hypertension than that in the moderate hypertension group (P<0.05). Incidence of osteoporosis in patients with moderate cerebral infarction and severe cerebral infarction was significantly higher than that in the mild cerebral infarction group (P<0.05). Incidence of osteoporosis in patients with severe cerebral infarction was significantly higher than that in the moderate cerebral infarction group (P<0.05). The results indicated that there is a close correlation between senile osteoporosis and hypertension, coronary heart disease and cerebral infarction. Osteoporosis can be used as a predictor of early screening for hypertension, coronary heart disease and cerebral infarction in the elderly population.
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