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Translating Mechanobiology to the Clinic: a panel discussion from the 2018 CMBE Conference
Alisa Morss Clyne1, Michele Marcolongo1, Eric M Darling2
1Drexel University, Philadelphia, PA USA.
Abstract:
The 2018 BMES Cellular and Molecular Bioengineering (CMBE) Conference was organized around the theme of Discovering the Keys: Transformative and Translational Mechanobiology. The conference programing included a panel discussion on Translating Mechanobiology to the Clinic. The goal of the panel was to initiate a dialog and share pearls of wisdom from participants' successes and failures in academia and in industry toward translating scientific discoveries in the field of mechanobiology to technology products in the market or toward devices or drugs that impact clinical care. This commentary reviews the major themes and questions discussed during the panel, including defining translational research and how it applies to mechanobiology, the current landscape in translational mechanobiology, the process for translating mechanobiology research, challenges in translating mechanobiology research, and unique opportunities in translating mechanobiology research.
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Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation
Translation Produces the Building Blocks of Life
Proteins are...
Initiation of Translation
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
Termination of Translation
Termination of Translation

