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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Advances in Nanomaterials for Brain Microscopy.

Jackson Travis Del Bonis-O'Donnell¹, Linda Chio¹, Gabriel F Dorlhiac¹

¹Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.

Nano Research

|May 21, 2019

Summary

New nanomaterials and deep-tissue microscopy techniques enhance in vivo brain imaging. These advances improve visualization of neural circuits, brain structure, and neurochemistry for better understanding of brain function.

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Published on: December 25, 2017

Area of Science:

Neuroscience
Materials Science
Biomedical Engineering

Background:

Microscopic brain imaging is crucial for understanding neural circuits.
Current methods face challenges in visualizing deep brain structures through dense tissue.
Improved visualization of brain structure, activity, and neurochemistry is needed.

Purpose of the Study:

To review current brain microscopy methods.
To describe nanomaterials used as contrast agents and probes for brain imaging.
To highlight advances in deep-tissue microscopy and nanomaterial engineering.

Main Methods:

Review of existing literature on brain microscopy techniques.
Analysis of recent developments in nanomaterial science for optical imaging.
Discussion of engineering chemical and optical properties of nanomaterials.

Main Results:

Nanomaterials offer tunable chemical functionality for neurochemical targeting and sensing.
Engineered nanomaterials provide enhanced fluorescence stability for long-term imaging.
Advances in deep-tissue microscopy enable imaging through optically-dense tissues.

Conclusions:

Nanomaterials and advanced microscopy hold significant promise for in vivo brain imaging.
These technologies can overcome current limitations in visualizing neural circuits.
Future research can leverage these tools for deeper understanding of brain function and disease.